by Scholten A

Medications for Premenstrual Syndrome (PMS)

The information provided here is meant to give you a general idea about each of the medications listed below. Only the most general side effects are included, so ask your doctor if you need to take any special precautions. Use each of these medications as recommended by your doctor, or according to the instructions provided. If you have further questions about usage or side effects, contact your doctor.
If your premenstrual syndrome (PMS) symptoms do not improve after 2-3 months of lifestyle changes, your doctor may recommend drug therapy. The following drugs may be used to treat PMS symptoms:

Prescription Medications

  • Combination of estrogen and progestin
  • Progestin only
  • Citalopram
  • Fluvoxamine
  • Paroxetin
  • Fluoxetine
  • Sertraline
  • Alprazolam
  • Lorazepam

Prescription Medications

Oral Contraceptives
Since hormonal contraceptives suppress ovulation, they may be able to provide PMS relief in many women. Depending on your medical history and risk factors, your doctor may prescribe combined oral contraceptive pills (which contain both estrogen and progestin) or a progestin-only contraceptive.
Possible side effects include:
  • Mood changes
  • Breast tenderness
  • Headaches
  • Unpredictable spotting (usually resolves after first 3 cycles)
Selective Serotonin Reuptake Inhibitors (SSRIs)
Common names include:
  • Citalopram
  • Fluvoxamine
  • Paroxetin
  • Fluoxetine
  • Sertraline
Serotonin reuptake inhibitors (SSRIs) affect the concentration of the neurotransmitter serotonin in the brain. These medication are used in the treatment of premenstrual dysphoric disorder (PMDD), a more uncommon and severe form of PMS. The medication can help relieve depression , irritability, and some of the physical symptoms. SSRIs may also offer benefit to women who have severe PMS, but are not diagnosed with PMDD.
SSRIs tend to work much faster in relieving depressive symptoms associated with PMS than the symptoms of major depression. This is why it is important for your doctor to correctly diagnose you. Depending on your condition, you may only need to take SSRIs during the 2-week premenstrual period.
Possible side effects include:
  • Nausea
  • Diarrhea
  • Insomnia
  • Sexual dysfunction
  • Weight gain
  • Risk of severe mood and behavior changes, including suicidal thoughts in some people (Young adults may be at a higher risk for this side effect.)
Common names include:
  • Alprazolam
  • Lorazepam
Benzodiazepines may be helpful if you have severe premenstrual anxiety that is not relieved by SSRIs or other treatments. These drugs must be used carefully because they can cause dependency if used on a regular basis for three months or more. It may be best to use these drugs only a few days a month when symptoms are most severe.
Possible side effects include:
  • Drowsiness
  • Lightheadedness

Special Considerations

If you are taking medications, follow these general guidelines:
  • Take the medication as directed. Do not change the amount or the schedule.
  • Ask what side effects could occur. Report them to your doctor.
  • Talk to your doctor before you stop taking any prescription medication.
  • Plan ahead for refills if you need them.
  • Do not share your prescription medication with anyone.
  • Drugs can be dangerous when mixed. Talk to your doctor if you are taking more than one drug, including over-the-counter products and supplements.


Premenstrual syndrome. EBSCO DynaMed website. Available at: Updated June 14, 2012. Accessed August 24, 2012.
Premenstrual syndrome. American Congress of Obstetricians and Gynecologists website. Available at: Accessed August 24, 2012.
Premenstrual syndrome (PMS) fact sheet. Office on Women's Health website. Available at: Accessed August 24, 2012.

Revision Information

Health Library Search

Only show results from the selected categories.

Coaptite is a gel-like substance that is used as a bulking agent. It is injected around the sphincter where the urethra and bladder meet. Sphincter muscles control the re...

Urethral suspension is a surgery to correct stress incontinence in women. Female Bladder and UrethraCopyright © Nucleus Medical Media, Inc....

Urethral suspension is a surgery to correct stress incontinence in women. The procedure creates support for the tube that carries urine out of the body. The tube is calle...

Stress incontinence is one of the many causes of uncontrolled leaking of urine. Urethral suspension is a surgery to correct incontinence in women. The incontinence is mo...

Bladder suspension is a surgery to reduce or correct stress incontinence in women. This process uses stitches to support the bladder and urethra. The bladder is the organ...

Ovarian cyst removal is surgery to remove a cyst or cysts from one or both of your ovaries. A laparoscopic surgery uses small incisions and specialized tools. It may offe...

Urinary incontinence is the loss of voluntary bladder control that can lead to urine leakage. Incontinence can be temporary or long-lasting....

Premenstrual dysphoric disorder (PMDD) occurs just prior to menstruation and is characterized by significant: PMDD is much more severe and less common than premenstrual ...

10 Vulvodynia condition

Vulvodynia is chronic pain or discomfort of the vulva. The vulva includes the: Female GenitaliaCopyright © Nucleus Medical Media, Inc....

11 Vaginismus condition

Vaginismus is an uncontrolled, involuntary spasm of the muscles that surround the vagina. These spasms cause sexual intercourse to be painful. It is a complex disorder. I...

Painful menstrual periods, also called dysmenorrhea, may include pain in the pelvis, abdomen, back, or legs, abdominal cramps, headache, and fatigue. Most women have pain...